International diversification Essay Example | Topics and Well Written Essays - 3000 words

International diversification - Essay Example International diversification occurs when a company trade in more than one country and is measure by the number of the countries the company occupy (Hwee 2007, p.17). Firms are always seeking for ways to increase their activities (Moncada-Paterno-Castello at el 2011, P.586). It can be through portfolio diversification, acquisition, Merger or resource investment (Hwee 2007, p.17). In recent ties international diversification has been made easier by Formation of trade organizations and minimized trade barrier allowing the companies to expand internationally (Gaur and Kumar 2009, P.172). A company may choose to diversify internationally despite its size provided it has products that can be used across the boarder. However according to Hwee (2007, p.17) requires huge capital investment due to marketing, restructuring of the management team, research to understand the new market and other investments while the growth may be hindered by other factors such as cultural values, political stab ility and exchange rates. There is contradicting information on whether diversification is beneficial to a company or not (Marcelo at el 2008). This paper will critically analyze the advantages and disadvantages of a company diversifying internationally. Advantages Growth A company diversifies internationally to new market one such company is the South Korea based Samsung electronics that has intensified its marketing globally and the outcome has been positive. Samsung electronics is a subsidiary of Samsung group and is the leading mobile phone manufacturer after overtaking the Nokia Company. Electronic companies are expanding like any other business to acquire their market share (Jaemin and Chan-Olmsted 2005, P.183) Samsung electronics especially mobile Phones has Increased its market share by export its products internationally as well as manufacturing products which are affordable by low income earners, mid income earners and high income earners. Africa is one of the fastest grow ing Mobile phone markets with recent study showing Africa as one of the continent with more mobile phone subscribers than landline users. In Fact, analysts estimates that Mobile Phone use in the last five years has been increasing at a rate of 65 percent per year. The growth s associated with the fact that they are the major means of communication, networking and also development (Kreutzer 2009, P.1). The leading Mobile manufactures have tapped into this opportunity by designing products that fits the Africa Market and setting up offices to drive their goals. This is also China is focusing to grow manufacturing its Market in Africa (Brenton and Walkenhorst 2010, P. 577). According to Thinesen (2011), Samsung is leading in the mobile phone Market share with about 25.3 percent of the total market share. Samsung electronics has realized growth in their mobile phone market share in Africa and USA overtaking Nokia in 2012 (Jackson 2012), for the first time in a long period Nokia has been replaced as the leading company. It has intensified its Marketing strategy, increased its investment in new mobile application, and rolled out offices in new territory and their investment has paid of thus the realized growth. Globally, according to international data corporation mobile phone sales grew by 2.4 percent in the third quarter of 2012 with total sales amounting to 444.5 millions units compared to 434.1

As Good As It Gets Essay Example for Free

As Good As It Gets Essay Being a good person has to do with someone discovering themselves and his or her role in the world. Some people think that being a good person is as simple as not harming another, but it is not always about what someone does not do, but what they do for others. Character is what makes people believe that others are successful. Everyone must do his or her part everyday by living a life of integrity. Having good character is much more than what people think it is; others can see someone’s true character better than the person themself. Some examples of good character include being trustworthy, respectful, and responsible. First, being trustworthy plays a huge role of having good character. In other words, trustworthy means being able to be trusted by others. People have to learn to keep their word in order to be trustworthy. If someone says he or she will do something for another person, that person expects them to keep their word. Obviously, trustworthy means having trust. If someone is not honest or being truthful, it is hard to say that person has good character. Being honest is a huge key in being trustworthy and having good character. To many people, it is extremely difficult to be friends with someone he or she cannot trust. Having the courage to do what is right is also an example of trustworthiness. Being trustworthy shows that someone can be a good person and deep down they do care about others. In addition, having and showing respect is another example of having good character. Being respectful generally means showing others respect and being polite to others. People need to learn to respect one another and show they have good manners. Saying yes ma’am and no sir is a way of showing respect and good manners. Being respectful shows a great amount about a person. It shows how he or she treats others and how they were raised. Some people were raised without their parents teaching them how to be respectful. People should treat others the way that they want to be treated. No one wants to be treated badly, so they should not treat others that way. Also, listening to what others have to say is being respectful. It is extremely rude to not listen to someone while they are speaking. People should not j udge others before they get to know them; people never know what others have been through until they get to know them. Last, responsibility also is a huge part of having good character.

Composition Of Amlodipine Besylate Tablets Biology Essay

Composition Of Amlodipine Besylate Tablets Biology Essay (28) Karalis et al in 2008 discussed the issues in the conference involved physiological factors affecting drug absorption, the role of pre-systemic effects on bioavailability (BA), the impact of variability in bioequivalence (BE) studies, and a final closing panel session on unresolved issues in BA/BE regulations. Several important aspects of drug absorption were highlighted. It was presented how the complexity of gastrointestinal (GI) physiology and the site dependent absorption can impact on drug BA. Similarly, the effects of food and formulation were also studied. The second session focused on integrating the complexities of GI into modeling the inter-individual variability of absorption and the prediction of first-pass metabolism from in-vitro data. The necessity to measure metabolites, the value of Biopharmaceutical Classification System (BCS), and the more recently proposed Biopharmaceutical Drug Disposition Classification System (BDDCS) were assessed as well. This session clo sed with presentations of pharmacokinetic software delegates. In the second day of the conference, the problem of high intra-subject variability in BE studies was analyzed. Study design considerations, the use of multiple-dose studies and the role of statistics in BE were also highlighted. Finally, the current thinking of regulatory authorities (EMEA and US-FDA) was presented. The conference closed with a last session on unresolved issues in the regulatory level. EXPERIMENTAL Tablets are the most popular dosage forms of Pharmaceutical product. A typical tablet formulation consists of the Active Pharmaceutical ingredient(s), fillersdisintigrant, lubricant and other inactive ingredients (e.g. binder, glidant and colors) a formulation scientist must conduct a thorough both to optimize a formulation so that it meets all specification and to ensure safety and efficacy. The specification for pharmaceutical tablets usually include appearance, weight, uniformity of contant, diameter, Thickness, friability, dissolution, disintegration, Hardness, Assay, Organolaptic character other product specific requirements. These specifications are established to ensure that the tablets will have sufficient mechanical strength to withstand packaging, shipping and handling and are physically and chemically stable to deliver the accurate amount of drug at the desired dissolution rate when consumed by the patient. Any changes in these characteristics may significantly affect the safety and efficacy of the product. FORMULATION DEVELOPMENT OF AMLODIPINE BESYLATE BY DIRECT COMPRESSION METHOD Direct compression is a preferred manufacturing process for pharmaceutical tablets, according to survey conducted by Shangraw and Demarest. In this study Amlodipine besylate was directly compressed by using three different formulation i.e. with different diluent,bibder,filler,disintigrant and lubricant.In this study we were not only study the biowaivers effect of different marketed brands and formulation of Amlodipine Besylate but also manufactured and developed three different formulation by reducind the cost and increased quality perspects. MATERIAL AND METHOD CHEMICALS. COMPOSITION OF AMLODIPINE BESYLATE TABLETS. FORMULATION NO.1 S.NO. Material Name Quanty per Tablet (mg) Percentage composition (%) Quantity for 100 tablets (gm) 1 Amlodipine Besylate 5 5 0.5 2 Avecil 102 47 47 4.7 3 Starch Pregelitinized 47.75 47.75 4.775 4 Magnesium stearate 0.25 0.25 0.025 Target compression weight is 100mg containing 5 mg active FORMULATION NO.2 S.NO. Material Name Quanty per Tablet (mg) Percentage composition (%) Quantity for 100 tablets (gm) 1 Amlodipine Besylate 5 5 0.5 2 Avecil 101 47 47 4.7 3 Avecil 102 47 47 4.7 4 Magnesium stearate 1 1 0.1 Target compression weight is 100mg containing 5 mg active FORMULATION NO.3 S.NO. Material Name Quanty per Tablet (mg) Percentage composition (%) Quantity for 100 tablets (gm) 1 Amlodipine Besylate 5 5 0.5 2 Avecil 102 49 49 4.9 3 Dicalcium Phosphate Anhydrous 44 44 4.4 4 Sodium Starch Glycolate 4 4 0.4 5 Magnesium stearate 1 1 0.1 Target compression weight is 100mg containing 5 mg active EQUIPMENTS Rotary press ( ZP19) Electronic Balance (Sartorious TE 214S) Mixer ( polyethylene bag ) Sieve # 20 METHOD Three new formulation of Amlodipine Besylate were developed using three directly compressible agents i.e. microcrystalline cellulose (Avecil 101 and 102), starch pregelatinized and Dibasic Calcium Phosphate in order to check the multi purpose excipients. First active and all excipients were weighed accurately using Sartorious TE 214S, The weighed materials were screened through 20 mesh size sieve and then mixing of powders was performed by geometric dilution method in polythene bag. First active was mixed with diluents by tumbling action and then one by one other ingredients of formulation were mixed together. All the ingredients were thoroughly mixed to ensure uniform distribution of all the ingredients throughout the formulation. Flow chart of manufacturing process Weighing of active and excipients Sieving y 20 mesh size Mixing of active and diluent Addition of other ingredients Addition of lubricant and mixing Tableting PHYSICAL TESTING OF TABLET Amlodipine Besylate tablets were evaluated for their physical and chemical properties by performing different pharmacopoeial test, i.e by official and unofficial tests including tablets weight variation, hardness, friability, disintegration, dissolution, Thickness, diameter and content uniformity and results were statistically analyzed and compared with marketed brands of Amlodipine Besylate named as test formulation # 1, test formulation # 2, test formulation # 3 TABLET THICKNESS AND DIAMETER The dimensional specifications of tablets are important for many reasons. The measurement of the thickness and the diameter of a tablet usually accomplished by the use of micrometer (Vernier) calipers. The value is initially employed as in process control during production. UNIFORMITY OF THICKNESS EQUIPMENTS Vernier caliper METHOD Tablet thickness is determined with a caliper or thickness gauge, which measures the thickness in millimeters. In this study, twenty tablets were taken and their thicknesses were determined using vernier caliper. Results were statistically analyzed using three sigma control chart. LIMITS A plus or minus 5% standard deviation may be allowed, depending on the size of the tablet.Out of twenty tablets only two tablets will be allowed to exceed the limit. UNIFORMITY OF DIAMETER OF TABLETS EQUIPMENT Vernier caliper METHOD Twenty tablets were taken and their diameters were determined using vernier caliper. . Results were statistically analyzed using three sigma control chart. LIMITS A deviation of  ±5% from the stated diameter is allowed except that for diameters exceeding 12.5mm the deviation allowed is  ±3%.Out of 20 tablets only 2 tablets will be allowed to exceed the limit. FRIABILITY TEST A certain weight of tablets ,are subjected to a well defined level of agitation in a fixed geometry,closed container for a specific time.They are then again reweighted.The measure of abrasion resistance or FRIABILITYis usually expressed as a percentage loss in weight. EQUIPMENT Electronic Balance (Sartorious TE 214S) Friabilator (Erweka Germany) METHOD Preweight samples of 20tablets were taken and subjected to the combined effect of shock abrasion by utilizing the plastic chamber which revolved at 25rpm for 4minutes, droped the tablet at a distance of 6 inches with each revolution. Then the tablets were removed, dedusted and reweighed. LIMITS Values of friability of 0.8 to 1.0% are frequently quoted as the upper level of acceptability for pharmaceutical product. Generally the test is run once. If the results are doubtful for if weight loss is greater than 1% repeats the test twice and determines the mean of the three tests. A maximum weight of 1% of the weight of the tablets to be tested is considered to be acceptable for most products. HARDNESS TEST This test is intended to determined under defined conditions,the resistance to crushing of tablets,measured by the forced needed to disturp them by crushing apparatus.Probably the most widely used technique is testing of crushing strength presisly defined as that compressional force which,when applied diametrically to a tablet,just fractures it. EQUIPMENT Hardness tester (Pharma test) METHOD Twenty tablets of every sample of brands and test formulation were taken and their hardness was determined using Pharma test hardness tester. In this type of tester load is applied at a constant rate by an electric motor. Results were statistically analyzed using three sigma control chart. LIMITS Hardness will be measured in kg.Out of twenty tablets; only two tablets are allowed to exceed the limit. DISINTIGRATION TEST FOR TABLETS Disintegration Test determines whether tablets or capsules disintegrate within the prescribed time when placed in the liquid medium in the experimental condition prescribed. For compressed uncoated tablets the testing fluid is usually water at 37  °C, but in some cases monographs direct that simulated gastric fluid TS be used. This test is provided to determine whether tablets or capsules disintegrate within the prescribed time when placed in a liquid medium under the experimental conditions presented below. For the purposes of this test, disintegration does not imply complete dissolution of the unit or even of its active constituent. Complete disintegration is defined as that State in which any residue of the unit, except fragments of insoluble coating or capsule shell, remaining on the screen of the test apparatus or adhering to the lower surface of the discs, if used, is a soft mass having no palpably firm core. Use apparatus A for tablets and capsules that are not greater than 18 mm long. For larger tablets or capsules use apparatus B. APPARATUSà ¢Ã¢â€š ¬Ã†â€™ The apparatus consists of a basket-rack assembly, a 1 liter, low-form beaker, 149  ± 11 mm in height and having an inside diameter of 106  ± 9 mm for the immersion fluid, a thermostatic arrangement for heating the fluid between 35  °C and 39  °C, and a device for raising and lowering the basket in the immersion fluid at a constant frequency rate between 29 and 32 cycles per minute, through a distance of 55  ± 2 mm. The volume of the fluid in the vessel is such that at the highest point of the upward stroke the wire mesh remains at least 15 mm below the surface of the fluid, and descends to not less than 25 mm from the bottom of the vessel on the downward stroke. At no time should the top of the basket-rack assembly become submerged. The time required for the upward stroke is equal to the time required for the downward stroke, and the change in stroke direction is a smooth transition, rather than an abrupt reversal of motion. The basket-rack assembly moves vertically along i ts axis. There is no appreciable horizontal motion or movement of the axis from the vertical. BASKET-RACK ASSEMBLYà ¢Ã¢â€š ¬Ã†â€™ The basket-rack assembly consists of 6 open-ended transparent tubes, each 77.5  ± 2.5 mm long and having an inside diameter of 21.85  ± 1.15 mm and a wall 1.9  ± 0.9 mm thick; the tubes are held in a vertical position by 2 plates, each 90  ± 2 mm in diameter and 6.75  ± 1.75 mm in thickness, with 6 holes, each 24  ± 2 mm in diameter, equidistant from the centre of the plate and equally spaced from one another. Attached to the under surface of the lower plate is a woven stainless steel wire cloth, which has a plain square weave with 2.0  ± 0.2 mm mesh apertures and with a wire diameter of 0.615  ± 0.045 mm. The parts of the apparatus are assembled and rigidly held by means of 3 bolts passing through the 2 plates. A suitable means is provided to suspend the basket-rack assembly from the raising and lowering device using a point on its axis. The design of the basket-rack assembly may be varied somewhat provided the specifications for the glass tubes and the screen mesh s ize are maintained. The basket-rack assembly conforms to the dimensions. DISCSà ¢Ã¢â€š ¬Ã†â€™ The use of discs is permitted only where specified or allowed. Each tube is provided with a cylindrical disc 9.5  ± 0.15 mm thick and 20.7  ± 0.15 mm in diameter. The disc is made of a suitable, transparent plastic material having a specific gravity of 1.18-1.20. 5 parallel 2  ± 0.1 mm holes extend between the ends of the cylinder. One of the holes is centered on the cylindrical axis. The other holes are centered 6  ± 0.2 mm from the axis on imaginary lines perpendicular to the axis and parallel to each other. 4 identical trapezoidal-shaped planes are cut into the wall of the cylinder, nearly perpendicular to the ends of the cylinder. The trapezoidal shape is symmetrical; its parallel sides coincide with the ends of the cylinder and are parallel to an imaginary line connecting the centres of 2 adjacent holes 6 mm from the cylindrical axis. The parallel side of the trapezoid on the bottom of the cylinder has a length of 1.6  ± 0.1 mm and its bottom edge s lie at a depth of 1.6  ± 0.1 mm from the cylinders circumference. The parallel side of the trapezoid on the top of the cylinder has a length of 9.4  ± 0.2 mm and its centre lies at a depth of 2.6  ± 0.1 mm from the cylinders circumference. All surfaces of the disc are smooth. If the use of discs is specified, add a disc to each tube and operate the apparatus as directed under Procedure. The discs conform to the dimensions. The use of automatic detection employing modified discs is permitted where the use of discs is specified or allowed. Such discs must comply with the requirements of density and dimension. PROCEDUREà ¢Ã¢â€š ¬Ã†â€™ Place 1 dosage unit in each of the 6 tubes of the basket and, if prescribed, add a disc. Operate the apparatus using the specified medium, maintained at 37  ± 2  °C, as the immersion fluid. At the end of the specified time, lift the basket from the fluid and observe the dosage units: all of the dosage units have disintegrated completely. If 1 or 2 dosage units fail to disintegrate, repeat the test on 12 additional dosage units. The requirements of the test are met if not less than 16 of the 18 dosage units tested have disintegrated. EQUIPMENT Disintegrating Apparatus (Pharma Test) METHODà ¢Ã¢â€š ¬Ã†â€™ Test 6 tablets or capsules either by using 2 basket-rack assemblies in parallel or by repeating the procedure. In each of the 3 tubes, place 1 tablet or capsule and, if prescribed, add a disc; suspend the assembly in the beaker containing the specified liquid. Operate the apparatus for the prescribed period, withdraw the assembly and examine the state of the tablets or capsules. To pass the test, all 6 of the tablets or capsules must have disintegrated. LIMITS All tablets must disintegrate completely, if one or two tablets fails to disintegrate, the test is to be repeated using 12 tablets. Out of the 18 tablets then tested,16 must have disintegrated within the given period of time .The condition of the test are varied somewhat for coated tablets,buccal tablets and sublingual tablets. Disintegration time are included in the individual tablet monograph. For most uncoated tablets the period is less than 15 minutes although the time for some uncoated tablets varied greatly from this. WEIGHT VARIATION Most pharmacopoeias include a simple weight test on a specified number of tablet(N) which are weight individually and the arithmetic mean weight calculated.Limitations on the number of test tablets that may lie outside certain limits are than specified.However,in the USP the results of the assay are used to convert these weights into active ingredients content. EQUIPMENTS Electronic Balance (Sartorious TE 214S) METHOD Twenty tablets of every samples were taken randomly and eight individually, and then average weight was determined. LIMITS According to USP not more than two of the tablets must not differ by more than the percentage listed below, no tablet differs by more than double that percentage. Tablets that are coated are exempt from these requirements but most conform to the test for content uniformity if it is applicable. The USP has provided tolerance for the average weight of uncoated compressed tablets. These are applicable when the tablets contain 50mg or more of the drug substances or when the matter comprises 50% or more, by weight, of the dosage form. Average Weight %age Difference 130mg or less 10 â‚ ¬Ã‚ ¾130mg to 324 mg 7.5 More than 324mg 5 ASSAY: AMLODIPINE BESYLATE REAGENTS 0.1N Sodium Hydroxide in Methanol Dimethyl formamide (DMF) STANDARD SOLUTION 50mcg/ml of Amlodipine Besylate in DMF. SAMPLESOLUTION Extract appropriate quantity of powdered sample with DMF to get concentration of 50mcg/ml. PROEDURE To 2ml each of sample and standard solution, add 0.2ml of Sodium hydroxide solution and dilute to 10ml with DMF and measure the absorption of orange chromatogen at 450nm against reagent blank. Calculate the contents of amlodipine by comparison.(237) AMLODIPINE BESYLATE The tablets comply with the requirment stated under tablet and with the following requirment. CONTENT OF AMLODIPINE BESYLATE C20H25ClN2O5,C6H6O3S 97.0% to 102.0% (Anhydrous substance) CHEMICALS Sodium hydroxide pellets Methanol N-N Dimethyl Formamide EQUIPMENT AND GLASS WARES Electronic Balance (Sartorious TE 214S) UV-VIS spectrophotometer (Double beam Shimadzu 1650PC ) Volumetric Flask (100ml,Pyrex England) Volumetric Flask (10ml,Pyrex England) Pipettes (10ml Pyrex England) Pipettes (2ml Pyrex England) Conical Flasks (Pyrex England) Beaker (Pyrex England) Filter paper (Whatman #42) METHOD Weigh and powder 20tablets of amlodipine Besylate 5mg (DC). Take quantity of the powder containing 5mg of amlodipine Besylate (average weight) in a 100ml volumetric flask and add N-N Dimethyl Formamide into it and mix thoroughly with the help of magnetic stirrer and then make up the volume up to 100ml.Then take 2ml from first dilution into a 10ml volumetric flask, add 0.2l of 0.1N Sodium hydroxide solution in 10ml volumetric flask then make up volume with N-N Dimethyl Formamide.Then take the absorbance at 450nm on spectrophotometer and calculate the content of amlodipine Besylate. CALCULATION (AMLODIPINE BESYLATE mgtablet) % ASSAY = Abs of sp X__ 100 Abs of STD UNIFORMITY OF CONTENT The test for uniformity of content of single-dose preparations is based on the assay of the individual contents of active substance(s) of a number of single-dose units to determine whether the individual contents are within limits set with reference to the average content of the sample. Tablets containing highly potent medicaments present in milligram or microgram does may be subject to a large inter tablet variation. This may be due to failure to achieve a homogenous mix of active ingredient and exciient during manufacture. The test is not required for multivitamin and trace-element preparations and in other justified and authorized circumstances. Methodà ¢Ã¢â€š ¬Ã†â€™ Using a suitable analytical method determines the individual contents of active substance(s) of 10 dosage units taken at random. Apply the criteria of test A, test B or test C as specified in the monograph for the dosage form in question. Test A Tablets, powders for parenteral use, ophthalmic inserts, suspensions for injection Test B Capsules, powders other than for parenteral use, granules, suppositories, pessaries à ¢Ã¢â€š ¬Ã†â€™ Test C Transdermal patches Test A Tablets, powders for parenteral use, ophthalmic inserts, suspensions for injectionà ¢Ã¢â€š ¬Ã†â€™ The preparation complies with the test if each individual content is between 85 per cent and 115 per cent of the average content. The preparation fails to comply with the test if more than one individual content is outside these limits or if one individual content is outside the limits of 75 percent to 125 percent of the average content. If one individual content is outside the limits of 85 percent to 115 percent but within the limits of 75 percent to 125 percent, determine the individual contents of another 20 dosage units taken at random. The preparation complies with the test if not more than one of the individual contents of the 30 units is outside 85 percent to 115 percent of the average content and none is outside the limits of 75 percent to 125 per cent of the average content. CONTENT UNIFORMITY C.U = Abs of Sample X wt of std X 100 X 100 Abs of STD X 100 X LC * LC =Label claim DISSOLUTION This test is provided to determine compliance with the dissolution requirements for solid dosage forms administered orally. Apparatus 1 (Basket apparatus)à ¢Ã¢â€š ¬Ã†â€™ the assembly consists of the following: a vessel, which may be covered, made of glass or other inert, transparent material a motor; a drive shaft; and a cylindrical basket (stirring element). The vessel is partially immersed in a suitable water-bath of any convenient size or heated by a suitable device such as a heating jacket. The water-bath or heating device permits maintaining the temperature inside the vessel at 37  ± 0.5  °C during the test and keeping the dissolution medium in constant, smooth motion. No part of the assembly, including the environment in which the assembly is placed, contributes significant motion, agitation, or vibration beyond that due to the smoothly rotating stirring element. Apparatus that permits observation of the preparation and stirring element during the test is preferable. The vessel is cylindrical, with a hemispherical bottom and a capacity of 1 litre. Its height is 160-210 mm and its inside diamete r is 98-106 mm. Its sides are flanged at the top. A fitted cover may be used to retard evaporation.2 The shaft is positioned so that its axis is not more than 2 mm at any point from the vertical axis of the vessel and rotates smoothly and without significant wobble that could affect the results. A speed-regulating device is used that allows the shaft rotation speed to be selected and maintained at a specified rate, within  ± 4 per cent. Shaft and basket components of the stirring element are fabricated of stainless steel, type 316 or equivalent, to the specifications shown in Figure 2.9.3.-1. A basket having a gold coating of about 2.5  µm (0.0001 inch) thick may be used. The dosage unit is placed in a dry basket at the beginning of each test. The distance between the inside bottom of the vessel and the bottom of the basket is maintained at 25  ± 2 mm during the test. Apparatus 2 (Paddle apparatus)à ¢Ã¢â€š ¬Ã†â€™ Use the assembly from Apparatus 1, except that a paddle formed from a blade and a shaft is used as the stirring element. The shaft is positioned so that its axis is not more than 2 mm from the vertical axis of the vessel, at any point, and rotates smoothly without significant wobble that could affect the results. The vertical center line of the blade passes through the axis of the shaft so that the bottom of the blade is flush with the bottom of the shaft. The paddle conforms to the specifications shown in Figure 2.9.3.-2. The distance of 25  ± 2 mm between the bottom of the blade and the inside bottom of the vessel is maintained during the test. The metallic or suitably inert, rigid blade and shaft comprise a single entity. A suitable two-part detachable design may be used provided the assembly remains firmly engaged during the test. The paddle blade and shaft may be coated with a suitable coating so as to make them inert. The dosage unit is allowed to sink to the bottom of the vessel before rotation of the blade is started. A small, loose piece of non-reactive material, such as not more than a few turns of wire helix, may be attached to dosage units that would otherwise float. An alternative sinker device is shown in Figure 2.9.3.-3. Other validated sinker devices may be used. DISSOLUTION MEDIUMà ¢Ã¢â€š ¬Ã†â€™ 1.2 pH BUFFER DISSOLUTION MEDIA REAGENTS USED Htdrochloric Acid (Merck grade) Distilled and deionized water PREPARATION 0.1N HCl was used as 1.2pH buffer media. 4.5 pH BUFFER DISSOLUTION MEDIA REAGENTS USED Potassium Dihydrogen Phosphate (Merck,Germany) Distilled and deionized water PREPARATION 6.8gm of Potassium Dihydrogen Phosphate in1000ml DI water and adjust pH with Phosphoric acid. 6.8 pH BUFFER DISSOLUTION MEDIA REAGENTS USED 0.2M Potassium Dihydrogen hosphate 0.1M Sodium hydroxide Distilled and deionized water PREPARATION 0.2M KH2PO4 13.61gm of Potassium Dihydrogen hosphate in 500ml DI water. 0.1MNaOH 4gm in 500ml DI water. 6.8pH Buffer 250ml of 0.2M KH2PO4 and 112ml of 0.1MNaOH to make 1000ml with DI water. CALCULATION % age drug release = Abs of sp X100 Abs of STD SAMPLING SCHEDULE Sample were drawn at 5min then After 10min After 15min After 20min After 30min After 45min After 60min After 120min EXPERIMENTAL CONDITIONS Usual experimental conditions are e.g.: Apparatus: paddle/basket â‚ ¬Ã‚  Volume of dissolution medium: 900 ml â‚ ¬Ã‚  Temperature of the dissolution medium: 37  °C ±1 °C â‚ ¬Ã‚  Agitation: paddle apparatus usually 50 rpm, basket apparatus usually 100 rpm â‚ ¬Ã‚  Sampling schedule: e.g.5, 10, 15, 20, 30, 45, 60, and 120 min â‚ ¬Ã‚  Buffer: pH 1.2 (0.1 N HCl or SGF without enzymes), pH 4.5, and pH 6.8 (or SIF withoutenzymes); (pH should be ensured throughout the experiment; Ph.Eur. buffers recommended) CHEMICALS Buffer 1.2 pH (0.1N HCl) Buffer 4.5 pH Buffer 6.8 pH EQUIPMENT AND GLASS WARES Dissolution paddle apparatus Distillation plant Electronic Balance (Sartorious TE 214S) UV-VIS spectrophotometer (Double beam Shimadzu 1650PC ) Volumetric Flask (100ml,Pyrex England) Pipettes (10ml Pyrex England) Pipettes graduated(2ml Pyrex England) Conical Flasks (Pyrex England) Beaker (Pyrex England) Filter paper (Whatman #42) PREPARATION OF STANDERD Accurately weight the standard and poured it into 100ml volumetric flask. The volume was made with the respective buffer and mixed,the stock solution was obtained. Then pippet out 1.1ml from the stock solution into another volumetric flask again made the volume with the respective buffer solution .Mixed it properly by shaking that was the first dilution and the required strength of standard was achieved to analyse. PREPARATION OF SAMPLE Placed the tablets of each brand into the vessel of paddle dissolutionhaving 900ml of resoective dissolution media. Switch on the apparatus and collect the sample according to the respective sampling interval that is 5min, 10min, 15min, 20min, 30min, 45min, 60min, and 120min. Every time the withdrawn media was replaced by the freh media.

A Letter from Holden from Catcher in the Rye :: Catcher in the Rye J.D. Salinger Essays

A Letter from Holden from Catcher in the Rye Dear Holden, Hi mate, what’s gone wrong with you? I can’t believe this has happened to you. You were fine when I left, after Allie dying and all. You know when I last saw you I was with Rachel (The English Actress). Well I proposed to her and she said yes. I am organising our honeymoon and the wedding so I am a bit tied up at the moment. So that is why I am writing a letter and not coming down to see you in person. In your previous letter, on a few occasions, you seemed to talk as if you were a different person. I wanna give you some advice. It will be easier if I tell you how I would have acted, or how you should have acted, just to help you. I remember you told me about that guy, Stradlater, and he was going on a date with Jane. He asked you to do an essay for him. I wouldn’t have done it for him; you have got your own life, try living it brother. Why didn’t you tell him you didn’t want to do it for him? If he was an alright guy he would have stayed at the school and written it himself. He was walking all over you and he only did it because you did not have anything better to do, because you were getting kicked out of Pencey in a few days. The thing with you is that you just can’t help yourself. Stradlater started talking for ages about Jane Gallagher and his date with her and you were stunned by this information. So when you stopped talking he just asked you. â€Å"Will you do it for me then?† and you gave in to him. It didn’t take any persuasion. Nothing. Later on in your letter, you talked about meeting this pimp, Maurice, in a lift. He asked you if you wanted to have some fun that night. Why? Why did you say yes? You don’t have to have a prostitute to have a good time. They are for sick, old perverts, not a sixteen-year-old, Holden. When the girl turned up, you should have just given her the money and made her leave. You didn’t even have to talk to her. She had her own life and she either wanted to have sex or go back to sleep. When that pimp came back because you didn’t give the girl enough money you should have just given the money to him. In your description he sounded huge, so I would have given him it.

Twelfth Night Explores the Nature of Love

The play Twelfth Night explores many different types of love between it's characters. With so much love and so many different levels and kinds, love easily appears to be the central theme of the play from the complex love triangle between Viola, Oliva and Orsino to hinted at homosexual love from Antonio to Sebastion, it is easily the central theme. The first love in the play is Orsino's love for Olivia. Although Orsino has never met Oliva before in his life he claims to be madly in love with her and sends messenger after messenger to tell her of his love. This uneducated and mostly appearance related love could easily just be infatuation. This could be proven when Orsino quickly asks Viola to marry him as though he never loved Oliva to begin with. Another, but a lot different, example of love in Twelfth Night is the self love Malvolio has for himself. Malvolio only cares about his social rank, becoming a gentleman. Then when he receives the letter from â€Å"Olivia† he becomes ecstatic and even says that he will make him the real head of the house rather then just a steward if they marry. The plans to use Olivia's love for him as a tool to reach where he wants to be. Another example of love, and probably the most true, is Viola's love for Orsino. Viola's love for Orsino is the most true because Viola and Orsino really know eachother. They talk and spend time together, even if they are both â€Å"men† they manage to get to know eachother. Also their live seems true because even though she loves Orsino she would go try and â€Å"Woo† Oliva so Orsino could be happy. There is also little ways showing love in the play Twelfth Night. For instance the idea that Antonio loves Sebastian is brought up by the way he speaks to Sebastian and the way he comes to Llyria with him even though he can go to jail. The last example of love is Maria and Toby, we know that Maria's love is true but whether or not Toby loves her is a mystery. Oliva's love for Cesario, Toby and Maria, Oliva and Sebastian, â€Å"Oliva's† letter to Malvolio, Viola and Orsino, and Orsino's love for Oliva easily show that love is a central them in Twelfth Night.

Local Color In Huck Finn Essay

Huckleberry Finn, a tale about a boy and his struggles with the society in which he lives, is written by Samuel L. Clemens. In the story, Huck manages to escape from the custody of Widow Douglas and travels down the river to a nearby island where he encounters Miss Watson’s runaway slave, Jim. Together, they float down the Mississippi River, to find a new life, where they can live freely and easily. The Adventures of Huckleberry Finn is perhaps the finest example of â€Å"local color†, an emphasis which is laid on the surrounding settings. Throughout the novel, Clemens accents â€Å"local color† by illustrating the natural scenery, the way of thinking, and the distinct practices and folklore encompassing the area. The novel’s plot revolves around the Mississippi River. The river breaks all the barriers of the time period, between black and white, young and old, slave and free. With their many journeys on land, they invariably return at the raft. While stopped in a near by village, Huck and Jim manage to escape the king and the duke, seeking refuge on raft. â€Å"It was the raft, and mighty glad was we to get aboard of it again†(Clemens 1309). Later on in the novel, at the Phelps Farm plantation, Tom and Huck learn that Jim is held captive in a hut just beyond Aunt Sally’s house. They devise a scheme to get him out, involving digging a tunnel, sawing off a leg of a bed which Jim was chained to, using a rope ladder, and having Jim flee from a makeshift window. The plan runs smoothly, all three exiting through the man made hole, until Tom gets caught on a piece of wood, which creates a clamorous noise. At that moment, they began their retreat in a hurry. Fifteen men, equipped with rifles and dogs, begin their hunt for the three outlaws: â€Å"Then we struck out, easy and comfortable, for the island where my raft was; and we could hear them yelling and barking at each other†Ã‚ ¦Ã¢â‚¬ (Clemens 1442). They manage to, once again, get away seeking protection on the raft. The raft shielded both Huck and Jim from nearly every obstacle, yet slavery was still present no matter where they were. During the time this novel was set, just prior to the 1860’s, slavery prevailed all across the United States, especially in the South. Slaves were thought of as property for the white man to own, thus making them inferior. It was not until the Civil War where the slavery issue was addressed and eventually resolved. Throughout  the story, Huck and Jim travel down the Mississippi in search of freedom. Jim escapes from the possession of Miss Watson, fearing she was going to sell him down the river and thus separate him from his family. At one of their stops, at the Phelps farm, Huck hears a story from Tom’s Aunt Sally about an explosion on a boat: â€Å"It warn’t the grounding † that didn’t keep us back but a little. We blowed out a cylinder-head. Good Gracious! Anybody hurt? No’m. Killed a nigger. Well, it’s lucky; b ecause sometimes people do get hurt†(Clemens 1409). Ultimately, at the culmination of the novel, Miss Watson grants Jim his freedom, as stated in her will. Much of the population of this time based most of their practices and rituals on either the Bible or folklore. Jim, Miss Watson’s slave, had a hairball, taken from the fourth stomach of an ox. He believed this hairball was a prophecy, which truly spoke to him. In another episode, while Huck is stranded on Jackson’s Island, he hears loud explosions in the distance: â€Å"You see, they was firing cannon over the water, trying to make my carcass come to the top†(Clemens 1287). It was common knowledge of the time that when a dead body is in a river, the vibrations from the cannon ball will enable it to rise and float. Furthermore, residents believed that when quicksilver was put into loaves of bread, it would float to the dead carcass. The Adventures of Huckleberry Finn has numerous instances in which â€Å"local color† is present. Throughout the novel, heavy focus is laid upon the Mississippi River, and the villages close by. Common men and women used superstition and folklore to explain and solve life’s natural phenomena. Along with this is the portrayal of the brutal aspects, both physical and psychological, of slavery. At the conclusion of the novel, all hurdles are overcome, and Jim and Huck become free. Most of the population of this time was narrow-minded, being on the river, away from society, allowed Huck and Jim to overcome these bounds.